Need Chemical Modifications?
For a chemically modified version of our Custom RNA, we offer 2’-O-methyl analogs and 3’ phosphorothioate internucleotide linkages at the first three 5’ and 3’ terminal RNA residues. Chemically modified sequences can provide additional RNA stability with improvements in editing efficiency for particular cell types (e.g. Stem Cells, K562, Prokaryotic) and genomic targets that prove otherwise challenging to edit. If you’re interested in a chemically modified option, select Modifications from the dropdown menu when inputting your target sequence on the order page.