CRISPRevolution is a portfolio of synthetic RNA designed for CRISPR genome editing and research. Designed by you and built by Synthego, our products offer economical access to fully synthetic RNA for high fidelity editing and increased precision in genome editing.
Designed for consistent CRISPR gene edits, our synthetic single guide RNA (100-mer) requires no annealing and arrives ready for transfection.
Gene knockout using CRISPRevolution Synthetic RNA Kits with Cas9 nuclease protein is simple:
A CRISPR design tool (for example, MIT CRISPR Designer) is used to create a target sequence within a region of interest in the genome. This target sequence is then used to order CRISPRevolution synthetic RNA.
Genomic editing with CRISPRevolution Synthetic RNA Kits and Cas9 nuclease protein is performed by co-transfecting all components with a transfection reagent.
One may then observe phenotypes directly, or undertake a genetic screen to estimate gene editing efficiency prior to clonal cell line generation and characterization.
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