mRNA format

This User Guide covers important guidelines for storage, preparation, and getting started with our SpCas9 nuclease mRNA and gRNA.

SpCas9 is the industry-standard CRISPR nuclease, widely used for reliable and efficient genome editing across research applications. Delivered in mRNA format, SpCas9 enables transient nuclease expression, while maintaining strong on-target activity. Supported by extensive validation across cell types, SpCas9 nuclease mRNA and gRNA provide a flexible, scalable solution for advancing your gene editing workflows.

This User Guide provides step-by-step support for working with SpCas9 nuclease mRNA and guide RNA (gRNA), including:

  • Storage recommendations for SpCas9 nuclease mRNA and gRNA
  • Instructions for gRNA preparation and handling
  • Recommended gRNA controls for SpCas9 nuclease mRNA
  • Key tips for efficient delivery and transfection
  • Guidance on evaluating and interpreting editing outcomes

Download the SpCas9 nuclease mRNA and gRNA User Guide to accelerate your next therapeutic innovation.