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Apr20

This Week in CRISPR – Spotlight on CRISPR at International Malaria Conference

Posted by Heidi Gardner in This Week in CRISPR · No Comments

crispr_news

The CRISPR field is moving fast! Don’t worry, we’ve got you covered. Check in every week for a quick summary of the biggest news and developments in genome engineering research so you can stay up to date with what’s happening in the world of CRISPR.

This week we report on the positive news that technology pioneer turned philanthropist Bill Gates has come out in favor of using CRISPR to combat the deadly disease malaria.

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Apr19

Step-by-Step Guide for Analyzing CRISPR Editing Results with ICE

Posted by Jessica Roginsky in CRISPR · No Comments

ICE

CRISPR-based genome engineering revolutionized the gene editing field by making experimental workflows considerably easier, faster, and more efficient than previous methods. Still, generating reliable results from CRISPR edit data requires the help of robust software tools. As a consequence, a critical step in the gene editing workflow – analyzing the data – is often under-appreciated or over-looked.

Synthego has developed a new tool called ICE (short for Inference of CRISPR Edits) to make analyzing CRISPR experiments easier than ever. This tool was initially created to support the CRISPR analysis needs of Synthego’s scientists – there were simply no other suitable software tools available. We conducted thousands of CRISPR experiments and took what we learned from analyzing the results to build the ICE analysis tool. It’s now free for everyone to use at ice.synthego.com.

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Apr17

Avengers Assemble! Could CRISPR Be Used to Create (and Find) Hawkeye?

Posted by Heidi Gardner in CRISPR · No Comments

Avengers: Infitity War CRISPR

2012 saw the original Avengers movie release, three years later we were treated with Avengers: Age of Ultron, and later this month we will finally see the third installment of the franchise; Avengers: Infinity War.

Another Avengers movie means another world-shattering conflict, and another appearance of everyone’s quick-witted Romeo, Tony Stark. Strangely, Tony Stark, a.k.a. Iron Man, has not been the focus of fans in the run-up to the movie’s premiere. Hawkeye has become the most talked about character from the fans’ perspective.

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Apr13

This Week in CRISPR – Are CRISPR-Edited Foods Coming Soon to a Store Near You?

Posted by Heidi Gardner in This Week in CRISPR · No Comments

crispr_news

The CRISPR field is moving fast! Don’t worry, we’ve got you covered. Check in every week for a quick summary of the biggest news and developments in genome engineering research so you can stay up to date with what’s happening in the world of CRISPR.

This week we dive into the discussion around regulation of crops edited using CRISPR technology. This topic that has been discussed extensively in recent months, and we may have found further clarity in the past week.

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Apr11

CRISPR Conversation: How Ulster University Researcher Kathleen Christie is Using CRISPR in Her Ph.D.

Posted by Kevin Holden in CRISPR Conversation · No Comments

CC-blog
CRISPR Conversations are our way of highlighting the amazing work being done by CRISPR researchers worldwide. We select scientists to cover based on the overall impact of their work using CRISPR for new applications that are moving their field forward.

This week we spoke with with scientist Kathleen Christie, who likes to go by “Katie”, from Ulster University in Northern Ireland to discuss her work and her experience using our synthetic sgRNA kits.

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Apr06

This Week in CRISPR – Paper That Fueled Fear About CRISPR’s Off-Target Effects is Retracted

Posted by Heidi Gardner in This Week in CRISPR · No Comments

crispr_news

The CRISPR field is moving fast! Don’t worry, we’ve got you covered. Check in every week for a quick summary of the biggest news and developments in genome engineering research so you can stay up to date with what’s happening in the world of CRISPR.

This week we highlight the news that the 2017 Nature Methods paper that caused a stir with its claims that CRISPR created unexpected edits with relatively high frequency has now been officially retracted.

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Apr05

Meet the Animals Facing CRISPR

Posted by Kevin Bryant in CRISPR · 1 Comment

group-of-farm-animals-on-a-white-background-picture-id93217353
Human obsession with hybrid animals dates back centuries. The mythological chimera, for instance, was a ferocious fire-breathing animal that was part lion, part goat, and part snake. Although we are not creating such hybrid monsters in the lab, the importance of introducing foreign genes in animals for the benefit of mankind has not gone unrecognized.

Transgenic animals possess foreign genetic material incorporated in their genome. These genomic manipulations often produce physical traits in the animals that are normally absent. The applications of transgenic animals were initially limited to model systems for understanding human diseases and developing novel therapeutics, but researchers soon realized their potential in the food and biomaterials industries, giving further impetus to genome engineering research.

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Mar30

This Week in CRISPR – Using CRISPR to Avoid Unwanted Mutations & Prevent Antibiotic Resistance

Posted by Heidi Gardner in This Week in CRISPR · No Comments

crispr_news

The CRISPR field is moving fast! Don’t worry, we’ve got you covered. Check in every week for a quick summary of the biggest news and developments in genome engineering research so you can stay up to date with what’s happening in the world of CRISPR.

This week we highlight research from the labs of George Church and James Collins at Harvard and MIT. They have adapted the existing CRISPR-Cas9 technology we know and love to act as a so-called ‘mutation prevention system.’

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Mar28

Synthego Welcomes CRISPR Co-Inventor Dr. Jennifer Doudna to Our Advisory Board

Posted by Paul Dabrowski, CEO @ Synthego in Press Release · 2 Comments

blogI am humbled and excited at what we accomplished at Synthego in the past year; we closed our Series B fundraise, continued to grow our amazing team, and leveraged our resources to launch Synthego’s full stack genome engineering workflow (from Design through our CRISPRevolution Guaranteed Editing Kits to ICE Analysis), taking an innovative, industry-leading approach.

Today we extend our accomplishments with the announcement that Dr. Jennifer Doudna, a pioneer and luminary in the field of genome engineering, is joining Synthego’s advisory board. Dr. Doudna co-discovered the programmable gene editing capabilities of CRISPR six years ago, paving the way for modern genome engineering.

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Mar23

This Week in CRISPR – Editing RNA with Cas13d, Evolution of Limbs, Mechanisms of Antibiotic Resistance, and CRISPR Strategy & Standards

Posted by Heidi Gardner in This Week in CRISPR · No Comments

crispr_news

Struggling to keep up with the latest news from the world of CRISPR? We’ve got you covered – here’s a quick summary of CRISPR news for scientists and researchers who want to keep up to date with what’s happening in the world of CRISPR.

We say this just about every week – but really, this week has brought significant scientific advances both facilitated by CRISPR, and within the technology itself. We’ll begin by telling you about Arbor Biotechnologies, the so-called ‘limitless’ new biotech company that’s been backed by CRISPR pioneer Feng Zhang. They’ve been keeping their technologies under wraps for months, but this week they revealed what they believe is a new, more versatile type of CRISPR technology using the Cas13d enzyme. The enzyme is significantly smaller than Cas9 and therefore lends itself well to RNA editing. Coincidentally, a research study also using Cas13d was published this week by researchers at the Salk Institute in California, who are hoping that the new tool will provide a foundation for increased research activity for diseases like frontotemporal dementia – in which a toxic protein imbalance is caused by abnormal RNA processing. We’ll then move on to a new modification of CRISPR that relies on the use of Cas9 nickase enzymes; an innovative approach which scientists think may provide hope for treatment of Huntington’s disease. Next, we discuss two studies covering vastly different topics; the first used CRISPR to uncover the evolutionary origin of the limbs of modern-day vertebrates, and the second relied on CRISPR to unearth the unknown mechanisms by which resistance to non-ribosomal peptide antibiotics can arise. We wrap up with an article covering Synthego’s approach to changing the genome engineering field and helping researchers define their CRISPR strategy through full stack solutions that include software tools and automated RNA synthesis.

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CRISPR technology is democratizing genome engineering
Welcome to the CRISPRevolution blog! I'm your moderator, Kevin Holden, PhD. Please join me as we explore the exciting, rapidly emerging field of CRISPR genome engineering. A revolutionary tool that is transforming the scientific community by allowing scientists to engineer genomes with unprecedented levels of precision, efficiency, and flexibility.
Recent Posts
  • This Week in CRISPR – Spotlight on CRISPR at International Malaria Conference
  • Step-by-Step Guide for Analyzing CRISPR Editing Results with ICE
  • Avengers Assemble! Could CRISPR Be Used to Create (and Find) Hawkeye?
  • This Week in CRISPR – Are CRISPR-Edited Foods Coming Soon to a Store Near You?
  • CRISPR Conversation: How Ulster University Researcher Kathleen Christie is Using CRISPR in Her Ph.D.
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Synthego is a leading provider of genome engineering solutions. Our flagship product, CRISPRevolution, is a portfolio of synthetic guide RNA designed for CRISPR genome editing and research. Synthego’s vision is to bring precision and automation to genome engineering, enabling rapid and cost-effective research with consistent results for every scientist.
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