Step-by-Step Guide for Analyzing CRISPR Editing Results with ICE
Posted by Jessica Roginsky in CRISPR · No Comments
CRISPR-based genome engineering revolutionized the gene editing field by making experimental workflows considerably easier, faster, and more efficient than previous methods. Still, generating reliable results from CRISPR edit data requires the help of robust software tools. As a consequence, a critical step in the gene editing workflow – analyzing the data – is often under-appreciated or over-looked.
Synthego has developed a new tool called ICE (short for Inference of CRISPR Edits) to make analyzing CRISPR experiments easier than ever. This tool was initially created to support the CRISPR analysis needs of Synthego’s scientists – there were simply no other suitable software tools available. We conducted thousands of CRISPR experiments and took what we learned from analyzing the results to build the ICE analysis tool. It’s now free for everyone to use at ice.synthego.com.
Avengers Assemble! Could CRISPR Be Used to Create (and Find) Hawkeye?
Posted by Heidi Gardner in CRISPR · No Comments
2012 saw the original Avengers movie release, three years later we were treated with Avengers: Age of Ultron, and later this month we will finally see the third installment of the franchise; Avengers: Infinity War.
Another Avengers movie means another world-shattering conflict, and another appearance of everyone’s quick-witted Romeo, Tony Stark. Strangely, Tony Stark, a.k.a. Iron Man, has not been the focus of fans in the run-up to the movie’s premiere. Hawkeye has become the most talked about character from the fans’ perspective.
This Week in CRISPR – Are CRISPR-Edited Foods Coming Soon to a Store Near You?
Posted by Heidi Gardner in This Week in CRISPR · No Comments
The CRISPR field is moving fast! Don’t worry, we’ve got you covered. Check in every week for a quick summary of the biggest news and developments in genome engineering research so you can stay up to date with what’s happening in the world of CRISPR.
This week we dive into the discussion around regulation of crops edited using CRISPR technology. This topic that has been discussed extensively in recent months, and we may have found further clarity in the past week.
CRISPR Conversation: How Ulster University Researcher Kathleen Christie is Using CRISPR in Her Ph.D.
Posted by Kevin Holden in CRISPR Conversation · No Comments

CRISPR Conversations are our way of highlighting the amazing work being done by CRISPR researchers worldwide. We select scientists to cover based on the overall impact of their work using CRISPR for new applications that are moving their field forward.
This week we spoke with with scientist Kathleen Christie, who likes to go by “Katie”, from Ulster University in Northern Ireland to discuss her work and her experience using our synthetic sgRNA kits.
This Week in CRISPR – Paper That Fueled Fear About CRISPR’s Off-Target Effects is Retracted
Posted by Heidi Gardner in This Week in CRISPR · No Comments
The CRISPR field is moving fast! Don’t worry, we’ve got you covered. Check in every week for a quick summary of the biggest news and developments in genome engineering research so you can stay up to date with what’s happening in the world of CRISPR.
This week we highlight the news that the 2017 Nature Methods paper that caused a stir with its claims that CRISPR created unexpected edits with relatively high frequency has now been officially retracted.

Human obsession with hybrid animals dates back centuries. The mythological chimera, for instance, was a ferocious fire-breathing animal that was part lion, part goat, and part snake. Although we are not creating such hybrid monsters in the lab, the importance of introducing foreign genes in animals for the benefit of mankind has not gone unrecognized.
Transgenic animals possess foreign genetic material incorporated in their genome. These genomic manipulations often produce physical traits in the animals that are normally absent. The applications of transgenic animals were initially limited to model systems for understanding human diseases and developing novel therapeutics, but researchers soon realized their potential in the food and biomaterials industries, giving further impetus to genome engineering research.
This Week in CRISPR – Using CRISPR to Avoid Unwanted Mutations & Prevent Antibiotic Resistance
Posted by Heidi Gardner in This Week in CRISPR · No Comments
The CRISPR field is moving fast! Don’t worry, we’ve got you covered. Check in every week for a quick summary of the biggest news and developments in genome engineering research so you can stay up to date with what’s happening in the world of CRISPR.
This week we highlight research from the labs of George Church and James Collins at Harvard and MIT. They have adapted the existing CRISPR-Cas9 technology we know and love to act as a so-called ‘mutation prevention system.’
Synthego Welcomes CRISPR Co-Inventor Dr. Jennifer Doudna to Our Advisory Board
Posted by Paul Dabrowski, CEO @ Synthego in Press Release · 2 Comments
I am humbled and excited at what we accomplished at Synthego in the past year; we closed our Series B fundraise, continued to grow our amazing team, and leveraged our resources to launch Synthego’s full stack genome engineering workflow (from Design through our CRISPRevolution Guaranteed Editing Kits to ICE Analysis), taking an innovative, industry-leading approach.
Today we extend our accomplishments with the announcement that Dr. Jennifer Doudna, a pioneer and luminary in the field of genome engineering, is joining Synthego’s advisory board. Dr. Doudna co-discovered the programmable gene editing capabilities of CRISPR six years ago, paving the way for modern genome engineering.
This Week in CRISPR – Editing RNA with Cas13d, Evolution of Limbs, Mechanisms of Antibiotic Resistance, and CRISPR Strategy & Standards
Posted by Heidi Gardner in This Week in CRISPR · No Comments