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CRISPR and Molecular Biology Resources

Explore our technologies and learn more about CRISPR genome engineering and Molecular Biology benefits, techniques, and more.

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Videos

Scaling CRISPR-Based Therapies: Overcoming Challenges in Development and Manufacturing

Live Webinar: June 10th, 2026, 12pm (PST)   CRISPR editing isn’t the bottleneck anymore. Scaling it is. Scaling isn’t just about producing more. The challenge is making CRISPR workflows reliable,...
Flyers

RPA Assay Execution and Optimization Checklist

This comprehensive checklist provides a standardized framework for executing and optimizing Recombinase Polymerase Amplification (RPA) assays using Synthego kits. It covers essential protocols for both DNA and RNA workflows, ensuring consistent performance across endpoint and real-time detection formats.
Protocols

SpCas9 nuclease mRNA and gRNA User Guide

mRNA format This User Guide covers important guidelines for storage, preparation, and getting started with our SpCas9 nuclease mRNA and gRNA.
Protocols

hfCas12Max nuclease mRNA and gRNA User Guide

mRNA format This User Guide covers important guidelines for storage, preparation, and getting started with our hfCas12Max nuclease mRNA and gRNA.
Flyers

Molecular Reagents Pricing Guide

Maximize your assay development budget with complete pricing transparency. Download our Molecular Diagnostics Pricing Guide for high-performance reagents across PCR, IVT, and isothermal amplification workflows.
Protocols

Limiting Dilution and Clonal Expansion Protocol

This protocol describes the use of limiting dilution to isolate single cells (clones) from a CRISPR edited population, the expansion of clonal populations, and screening to identify clones with the...
Protocols

SpCas9 Protein and gRNA User Guide

Thank you for choosing SpCas9 nuclease protein and gRNAs for your CRISPR experiment! SpCas9 has been used for diverse genome editing applications, making it the gold standard in CRISPR gene...
Videos

CRISPR to the Clinic and Beyond

Learn more about clinical applications of CRISPR and how Synthego can support you from early-phase research, through process development, and into the clinic, highlighting our new sgRNA GMP manufacturing capabilities
Flyers

Next-Generation GMP Facility

CRISPR therapies are revolutionizing medicine, making up 70% of current gene-editing trials. To accelerate the clinical development of CRISPR cell and gene therapies, Synthego has launched its new, state-of-the-art manufacturing facility. This flyer provides an insight into our new manufacturing capacity for the production of GMP-grade CRISPR sgRNAs.
Videos

Shaping Therapeutic Development with Cutting-Edge CRISPR Nucleases

This live webinar recording explores Synthego’s cutting-edge nuclease portfolio, featuring our newest engineered nuclease, eSpOT-ON. Casey Jowdy, Senior Product Manager at Synthego, dives into its development, how its on-target and off-target profile (fidelity) compares to other Cas9 variants, and demonstrates its therapeutic potential by treating familial hypercholesterolemia. Through detailed data analysis, you will gain a deeper understanding of how eSpOT-ON enhances genome editing efficiency and how you can start using it in your work today.
Protocols

AccuBase™ protein and gRNA User Guide

Protein format Get step-by-step guidance on storing, handling, and setting up your experiments with the AccuBase Cytosine Base Editor and gRNA.
Protocols

eSpOT-ON nuclease protein and gRNA User Guide

Protein format This User Guide offers key details on storing, handling, and initiating experiments with our eSpOT-ON nuclease protein and gRNA.
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