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Why Expand Beyond CRISPR? A Commitment to the Full CRISPR Workflow
Synthego's reputation was built on providing best-in-class, standardized CRISPR solutions that enabled researchers to accelerate their gene editing experiments with confidence. Through this journey, we gained a deep understanding of the entire experimental continuum—from initial target discovery and validation to downstream analysis. We recognized a critical need in the market for molecular biology reagents that match the high standards of quality and performance that our customers have come to expect.
Our CRISPR customers' research does not only require a successful gene edit. The complementary steps, including DNA amplification, RNA synthesis and analysis, and sequencing, are just as critical to achieving a meaningful outcome. Inconsistent or low-quality reagents in these downstream applications can compromise an entire project, leading to unreliable data and wasted resources. By providing a suite of trusted molecular reagents, we are empowering researchers to maintain experimental integrity from start to finish, ensuring their groundbreaking CRISPR work is supported by robust and reproducible downstream analysis.
Supporting the Demands of Molecular and Clinical Diagnostics
The field of clinical and molecular diagnostics is evolving at an unprecedented pace, with molecular techniques like polymerase chain reaction (PCR) and next-generation sequencing (NGS) becoming central to disease detection, monitoring, and personalized medicine. The accuracy of these diagnostic assays is paramount, as clinical decisions and patient outcomes depend on it. Sub-optimal reagents can lead to false negatives or positives, assay variability, and a lack of sensitivity, all of which are unacceptable in a clinical context.
Synthego’s new portfolio of molecular reagents is engineered to meet the stringent requirements of molecular and clinical diagnostics. Manufactured under rigorous quality control standards, these products ensure lot-to-lot consistency, superior performance, and high fidelity. For diagnostic labs developing and running complex assays, our reagents provide the reliability needed to deliver accurate results, time after time. Whether for pathogen detection, genetic screening, or cancer diagnostics, these tools are designed to provide the robust performance that clinicians and patients rely on.
Empowering Diagnostics Through Expert Lyophilization
For diagnostic assay developers, reagent stability is not just a technical detail—it is a critical determinant of commercial viability and clinical utility. Our deep expertise in lyophilization, refined over more than a decade, directly addresses this challenge by transforming liquid reagents into stable, ambient-temperature formats. This capability is fundamental to developing robust, scalable, and globally distributable diagnostic solutions.
We recognize that every diagnostic workflow has unique requirements. That’s why we provide comprehensive custom lyophilization options, empowering you to specify exact formulations, volumes, and formats tailored to your protocols. Whether you need specialized buffer components, unique concentrations, specific fill volumes, or custom packaging for integration into automated systems, our team delivers lyophilized reagents precisely configured for your applications. With collaboration at every step, and manufacturing through a validated lyophilization partner, we ensure your custom products are manufactured to the most stringent quality standards.
Contact us to learn more about customizing molecular reagents.
An Overview of the New Molecular Reagent Portfolio
Our new portfolio features key product families tailored to support critical steps in molecular biology and diagnostic workflows. With the flexibility to customize reagents—covering variables like volume, concentration, and formulation, including lyophilization through a validated manufacturer—we ensure seamless integration into optimized workflows, delivering maximum efficiency and reliable performance.
High-Fidelity PCR Enzymes for Precision Amplification
Polymerase chain reaction (PCR) is a cornerstone of modern molecular biology and a key determinant of successful molecular diagnostic assays. Synthego’s reagents are engineered for accuracy and robust amplification, whether the need is standard research, high-throughput diagnostics, or applications requiring exceptional fidelity. Featured products such as our Hot-Start, High-Fidelity DNA Polymerase and High Sensitivity Reverse Transcriptase serve as trusted tools that support everything from cloning and sequencing to difficult template amplification.
Tools for High-Yield RNA Synthesis and Analysis
Advancing RNA-focused research and diagnostics demands both yield and integrity, which is why Synthego’s IVT enzymes are purpose-built to drive results in even the most rigorous environments. Solutions such as our Engineered T7 RNA Polymerase provide high-yield, rapid in vitro transcription for applications ranging from guide RNA synthesis for CRISPR workflows to molecular assays for pathogen detection. To secure sample integrity throughout critical processes, our RNase Inhibitor stands as a reliable safeguard, protecting RNA from enzymatic degradation.
RPA Kits for Isothermal Amplification
Isothermal amplification has become an essential technology for rapid, sensitive nucleic acid detection, particularly in point-of-care and field-based molecular diagnostics. Synthego’s Recombinase Polymerase Amplification (RPA and RT-RPA) Kits are specifically designed to deliver fast, robust nucleic acid amplification without thermal cycling, making them indispensable for point-of-care and time-sensitive diagnostic applications. With customizable formats tailored for laboratory-developed procedures, commercial diagnostics, and research innovation, these RPA and RT-RPA kits provide trusted, efficient performance at constant temperatures, streamlining everything from pathogen detection to mutation screening and supporting flexible integration into optimized workflows.
Reagents for Seamless CRISPR Workflow Integration
For our existing CRISPR customers, this portfolio offers the tools necessary to complete their experimental workflows with the same level of quality they trust from our CRISPR solutions. After a successful edit, researchers need to validate their results through PCR and sequencing. Our high-fidelity DNA polymerase is the perfect tool for amplifying the edited genomic region to confirm the desired modification. Furthermore, researchers using CRISPR for functional genomics screens or developing RNA-guided nucleases can benefit from our T7 RNA Polymerase to in vitro transcribe high-quality gRNAs. By providing these essential reagents, we offer a more complete solution that takes a researcher's project from hypothesis to validated result within a single, trusted ecosystem.
Your Partner in Discovery and Diagnostics
The launch of our molecular reagents portfolio marks a significant milestone for Synthego and the scientific community we serve. It represents our unwavering commitment to empowering researchers and clinicians by providing them with the highest-quality tools needed to tackle their greatest challenges. By expanding beyond CRISPR, we are not just launching new products; we are reinforcing our role as a comprehensive partner in scientific advancement.
These reagents are engineered with precision, performance, and the user in mind, ensuring that whether you are conducting fundamental molecular biology research or developing a life-saving diagnostic test, you have solutions you can trust.
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Learn more about these products and discover how Synthego's new molecular reagent portfolio can elevate your research and diagnostic workflows.
